Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature

Chronic lung allograft dysfunction: evolving practice.

PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...

Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Chronic lung allograft dysfunction following lung transplantation: challenges and solutions

A new classification system for chronic lung allograft dysfunction.

Although survival after lung transplantation has improved significantly during the last decade, chronic rejection is thought to be the major cause of late mortality. The physiologic hallmark of chronic rejection has been a persistent fall in forced expiratory volume in 1 second associated with an obstructive ventilatory defect, for which the term bronchiolitis obliterans syndrome (BOS) was defi...

Prediction of chronic lung allograft dysfunction: a systems medicine challenge.

Affiliations: Clinique Universitaire de Pneumologie, Pôle de Cancérologie, Médecine Aiguë et Communautaire, CHU Grenoble, Inserm1055, Grenoble, Université Joseph Fourier, Grenoble, European Institute for Systems Biology and Medicine, EISBM, Lyon, Institut du Thorax, Inserm UMR1087, CNRS UMR629, Service de Pneumologie, CHU de Nantes DHU2020, Nantes, Université de Nantes, Nantes, Université Josep...